josephr

great piece by morpheus of weedtracker-

A brief overview of major cannabinoids, excluding THC, and the key essential oils of cannabis might be helpful to some patients. This article will be revised as I find new information to add. Much of the following was freely adapted from the book, "The Medicinal Uses of Cannabis and Cannabinoids", edited by Dr. Geoffrey Guy.

Remember, that I am not a doctor or a pharmacist and don't pretend to be either. Talk to your physician if you have concerns or questions about your use of medicinal cannabis. The following information is not intended to be prescriptive.

Cannabinoids are chemical compounds that are unique to the cannabis plant. "The Cannabinoids" is also the new name of Erykah Badu's band, but that's another story...

Mammals have two receptors: CB1 and CB2, in their tissues that interact with cannabinoids. CB1 receptors are found in the brain and central nervous system. It used to be thought that receptors and the compounds that act on them worked like a lock and key. More recent science indicates that receptors actually have a protein on them that interacts with these compounds.

CB1 receptors are also found in a variety of other tissues throughout the body including immune cells, reproductive and gastrointestinal tissues, the adrenal and pituitary glands, plus the heart, lungs and bladder. CB1 receptors are concentrated on the neurons associated with pain perception, both inside the brain and outside it. Mammals produce their own range of compounds, called endocannabinoids, which act on these receptors. The structure of these CB1 and CB2 receptors vary among different mammals, but not by much.

CB1 and CB2 receptors regulate the release of chemical messengers throughout the body. On the CB1 receptors, cannabinoids modulate the release of neurotransmitters within the central nervous system. On the CB2 receptors, cannabinoids modulate changes in the body's immune system by activating or suppressing their function, though the dosage required to achieve immunosuppression does not appear to be reached by high-dosage cannabis users. Both CB1 and CB2 receptors regulate pain.

The best-known cannabinoid is delta-9-tetrahydrocannibinol (THC), which is primarily responsible for the most notable psychoactive effect of cannabis.

THC is only one of over sixty cannabinoid compounds that are found in the plant. Other cannabinoids of significant interest to medicinal cannabis patients include cannibidiol (CBD), tetrahydrocannabivarin (THCV), cannabinol (CBN), cannabichromene (CBC) and cannabigerol (CBG).

CBD is found in only a few medicinal strains of cannabis in the US, even though it is reportedly common in Afghani and Pakistani hashish landrace strains. CBD does not have any psychoactive effect like THC, but does lengthen and mellow the psychoactive effects of THC. CBD does have significant benefits to medicinal cannabis patients including sedation, anticonvulsant effects, and it is a potent anti-inflammatory agent. CBD is also likely responsible for reducing THC-activated anxiety in some patients.

THCV is also rarely found in California cannabis. THCV content is associated with strains from Malaysia, Indonesia and southwest Africa. Malawi strains typically contain relatively high amounts of THCV. Recent researchers state that THCV is not psychoactive, while older studies claimed that THCV was psychoactive but only 25% as strong as THC. THCV has been shown in early studies to reduce obesity in research animals and may form the basis of future cannabis-derived drugs. We haven't tried any high THCV meds to see if they can reduce our tendency to consume entire pizzas after medicating...

CBN is not usually found in significant quantities in living cannabis, but it is produced when THC breaks down after exposure to air, heat or light. CBN does have a slight affinity for the CB1 receptor, which means it may be very mildly psychoactive. But CBN does have some anti-inflammatory effects.

CBC is found in some Afghani and Chinese strains. It is a potent antidepressant in animal tests, but usually the cannabis plant does not produce enough CBC to make this effect very significant.

CBG is the chemical precursor that the cannabis plant transforms into THC, CBD and CBC. High amounts of CBG are usually found only in hemp, not medicinal, strains. It is interesting to note research has shown that CBG has more analgesic effect than THC.

The medicinal effects of the essential oils in cannabis have only recently begun to be studied, but may help to explain some of the variations in effects noted by patients using different strains of medicinal cannabis.

Linalool is found in cannabis, but also in mint and citrus plants. It has noteworthy sedative effects.

Limonene - associated with some Thai strains, limonene is found primarily in citrus peel. It has significant antidepressant & immune-stimulating effects in animal tests. And limonene is one of the reasons that OG Kush smells so good. Some people are allergic to limonene and should avoid using cannabis that contains it.

Myrcene is the most common essential oil found in cannabis. Its smell is like balsam shampoo and it's responsible for the "green" aroma of some cannabis strains, like our Ginger Drop. Myrcene has potent analgesic and anti-inflammatory effects in animal models. Our patients indicate that high-myrcene content is likely responsible for mood-elevation effects, though we need much more data before making such a generalization.

Pinene is found in evergreens like pine. Pinene was very common in Hawaiian strains in the Eighties, but rare today. It has anti-inflammatory effects in animal studies.

I totally agree. The most I ever have to spend to get weed like that is $50 CAN for an 1/8th and thats if I'm forced to do a mail order. Who cares about the strain name anyways? I've had tons of great shit where my dealer didn't know what the name is. A name is just a name. I'd agree that the finished product has higher potential with good genetics, but it really comes down to how good the grower is.

to me this is the equivalent of drinking whatever swill is in the well. not even acknowledging the difference between a charles shaw and a nice barolo?

are all dark jeans the same? is a finely finished piece of west indian sea island cotton the same as high yarn number turkish shirting? i am just as otaku about weed as clothes, if you're not that's ok.

of course it's all about the grower - to me, you either have to know the grower or know that your "dealer" is legit.

how would you ever get what you liked again? i guess i am lucky because i get to go to the weed store. before i had a dr's rec. i used to use a long established home delivery service with pin numbers and shit and was $180/q minimum but they had a large menu of consistent and excellent shit and i paid it happily because like i said before i don't mind paying for excellence. i like being able to smoke pure sativas all day and purples at nitetime.

i bet most of you mfers are smoking kifed weed an shit anywayz.

cpBzQI_7ez8

does anyone here always get blown off of one fucking hit? ive been smoking for almost 3 years now and a hit is always how much it takes. i smoke more, but theres really no need to. this happens to anyone too?

it's best to smoke as little as possible to get you high. keeps your "tolerance" low.

i think that most people in LA are not smoking very good weed, for sure. and the weed that i smoke definitely comes from norcal, that is also for sure. i pay 65/e because i go to a nice medical cannabis dispensary that is so otaku about weed they keep it all in nice temperature/humidity controlled wine coolers. they probably have about 30 kinds at a time and they are all top-shelf. the prices range from ridiculously powerful outdoor hindu kush for 45 to the most beautiful examples of og kush for 65/e. most strains, which they get consistently and are otherwise rare are like 50-60 (malawi queeen, ultrawreck, various pure sativas, some proprietary purple kushes). i think this is well worth it for the selection and convenience. i can go any time from 11-7 everyday. i met madlib last time i was there.

this level of quality cannabis is available in only a few places, i'd swaguess california, canada, the netherlands, england, spain. probably not so good access, though. i don't doubt that the best cannabis can be grown anywhere because i think the best is realistically all indoor anyway.

my only point is that this talk about "gay strain names" is just ridiculous though. differing ratios of cannabinoids and essential oils (which make up the active ingredients of cannabis) are what make these differences. some are closer because they share more genetics, others are different because they descend from another lineage.

and as domdomd said they are big business.

to illustrate...these pics are from a photothread of weed from my dispensary.

this is purple nepali

and this is og kush

and this is a pure sativa

middleman middleman

http://www.newyorkhatco.com/item-details.php?GID=465&CATID=8

oh def...i was so disappointed to find out McQueen suits were fused

greenfield...TB isn't made by the same, is it?

the vast majority of designer suit jackets are fused from what i know.

i don't think greenfield is making for TB (could be, not sure) but they do bb golden fleece and some other stuff. there's a great one page on the greenfield factory in the april boon magazine.

on your next shirt i would suggest adding 1.5cm or more to the waist so it fits better untucked.

if they are that price i would rather pay the extra 3-400 for a thom browne, his summer cotton blazers seem to be the inspiration for some BoO stuff i've seen...TB stuff is incredibly well made and surprisingly fits on a lot of different body types. I'm 6'5 and the TB cotton jacket i tried on fit like a glove. This was a few seasons ago though, so they may very well cost $3k now. Also think he does the best Oxford shirt in the game now and they're not expensive ($250-ish IIRC)

band of outsiders suit jackets are made by martin greenfield and are full canvas/etc. so for the price they're probably a lot nicer than most "fashion" suits.

ok all this BS from the canadians is fucked. i could pay 40/e for shit weed too!

edit: did not mean that all canadians have shit weed. however, "beasters" is the name for weed from BC that comes to california...

strain names are serious business. there are many cultivars of cannabis and if you're fine with smoking shitty whatever weed that's all good but i am not! i look for provenance and good growing/curing above all else. weed has stupid names but if you get headband from a legitimate source you know it is a sour diesel x og kush cross.

these cultivars are stabilized, you can grow them over and over and the plants have similar effects/look/smell/taste. therefore if you know you like white widow snowcap SShaze or whatever you are into a particular kind of cannabis and if you like some gdp or whatever you like another.

anyway prices are inflated in socal definitely but i certainly don't mind paying 65/e for excellence.

og kush and sour diesel both share the a sort of "racy" high because they elevate your heart rate really rapidly, not good weed for people who get paranoid.

our weed taste is so similar. i am smoking a joint of og kush x cheese right now!

hi all, it's my first post here.

exile- i would have to say that sour diesel is better than purple kush (i didn't really like the high that i got from pk). however, i prefer og kush over sour diesel (but i think it depends on personal preference).

sour diesel - an insane flavor and relaxing high.

og kush - doesnt taste as good as sour diesel but it gives a much more intense high.

my top 5 strains of the moment:

-og kush

-trainwreck x super silver haze

-cheese

-white widow

-sour diesel

og kush is going for like 6k/lb still in socal. lots of dispensaries are still paying crazy prices so there's lots of $80/8ths around.

interesting thing about "tolerance" - a lot of this effect (smoke more, don't get more high) is because according to evidence from a recent UC study: low dose of cannabis - low pain relief. moderate dose - excellent pain relief. high dose - low pain relief. it is very important to NOT SMOKE TOO MUCH at a time. "overdosing" on cannabis is when you've smoked too much and feel groggy and just want to go to bed, but not particularly high.

WHAT ARE YOUR FAVORITE FIVE STRAINS (CULTIVARS)?

mine-

abusive og kush

malawi queen

sour diesel

headband

dj shorts blueberry

i haven't been because i can't stand h lorenzo. i love maxfield but they could use some competition.

abercrombie definitely has the heritage of an "all time classic brand" i mean shit in the 2nd mag from march kinji is wearing an old a&f jacket in the "my dear garment" section and those guys don't fuck around.

as for ralph lauren not going downhill...quality on polo stuff these days is pretty bad! purple label is nice though.

i think most brands we're talking about (esp american ones) are making pretty shitty products these days unless they're the overseas division (champion jp?) or almost strictly for export (woolrich, alden cordovan).

that is more of a fitting problem than anything inherently wrong with the suit i think.

here's thomas mahon talking about sleeve pitch.

Shuron Sidewinder Gray Tortoiseshell

aren't those freeways with the bar instead of the dots?

what are you talking about andrewweezer

stealing uh what? i just see some clothes...

this is interesting to me because the $500 price tag seems to make people think that the quality can't be there. the reason the price is so low is that he's a manufacturer/retailer. if he were selling these to stores they would probably cost $1000-1200 because of additional markup.

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Raf Simons Mainline Pull over Sweat W/ Epaulettes/etc SZ 50 (fits like 46-48) - $200

Retail was $300+. Worn about 3 times.

PATRIK ERVELL Wool/Cashmere SHORT JACKET SZ L - $275

Retail was about $450. Brand new. I can find the tags if you want.

All prices include shipping in the US - USPS Priority w/insurance and delivery confirmation. All items are 100% authentic.

Email at [email protected]

VISVIM G Ellis Border Shirt XL BRAND NEW WITH TAGS - $190

Retail was $264(+tax) at Union-

dudes if they looked similar it would be one thing but they are really exactly the same except for the bottom of the sole.

you can't copyright anything if it has a practical use. so there is nothing to prevent a company from selling 100% copies of something else (unless it's infringing on a trademark ex. PRADO) but it is pretty weak (h&m/forever 21 design piracy territory).

and a jil cotton hoodie!

man thank you for keeping it so real

your roomate again? ;]

i'm more than a little too big for the 40p.